腫瘤免疫和免疫治療/ 調節性B細胞在自身免疫性疾病和腫瘤中的作用及機制研究
儲以微，復旦大學(xué)教授，長(cháng)期從事腫瘤免疫與免疫生物治療，炎癌轉化的免疫學(xué)機制研究，以及B淋巴細胞與免疫調節。在腫瘤放化療后體內免疫系統重建及機制、TLRs抗腫瘤免疫效應及機制研究、以及腫瘤疫苗和CART設計等方面取得系列發(fā)現，研發(fā)了快速DC疫苗、第四代CART細胞免疫治療技術(shù)。主持和參與多項國家和省部級項目，包括國家自然科學(xué)基金重點(diǎn)項目、面上項目、國家重點(diǎn)研發(fā)計劃等。在國內外學(xué)術(shù)刊物上發(fā)表論文?251?篇，申請或授權專(zhuān)利10余項。主編規劃教材《免疫學(xué)與病原生物學(xué)》,《醫學(xué)免疫學(xué)》，以及人衛出版社英文教材《Medical Immunology》等。
聯(lián)系郵箱：Yiwei_chu@126.com
論文發(fā)表節選
Wanwei Zheng, Huan Song, Zhongguang Luo, Hao Wu, Lin Chen, Yuedi Wang Haoshu Cui, Yufei Zhang, Bangting Wang, Wenshuai Li, Yao Liu, Jun Zhang, Yiwei Chu*,?Feifei Luo*, Jie Liu*. Acetylcholine ameliorates colitis by promoting IL-10 secretion of monocytic myeloid-derived suppressor cells through the nAChR/ERK pathway. PNAS. 2021 118(11):e2017762118
Qian J, Luo F, Yang J, Liu J, Liu R, Wang L, Wang C, Deng Y, Lu Z, Wang Y, Lu M, Wang JY, Chu Y*.TLR2 Promotes Glioma Immune Evasion by Downregulating MHC Class II Molecules in Microglia. Cancer Immunol Res. 2018 6(10):1220-1233.
Qian J#, Wang C#, Wang B, Yang J, Wang Y, Luo F, Xu J, Zhao C, Liu R, Chu Y*.The IFN-γ/PD-L1 axis between T cells and tumor microenvironment: hints for glioma anti-PD-1/PD-L1 therapy. J Neuroinflammation. 2018 15(1):290(1-13)
Liu R, Lu Z, Gu J, Liu J, Huang E, Liu X, Wang L, Yang J, Deng Y, Qian J, Luo F, Wang Z, Zhang H, Jiang X, Zhang D, Qian J, Liu G, Zhu H, Qian Y, Liu Z,?Chu Y*. MicroRNAs 15A and 16-1 Activate Signaling Pathways That Mediate Chemotaxis of Immune Regulatory B cells to Colorectal Tumors. Gastroenterology. 2018;154(3):637-651
Lu Z, Liu J, Liu X, Huang E, Yang J, Qian J,3, Zhang D, Liu R*, Chu Y*. MiR-15a/16-1 Suppresses AHR-dependent IL-22 Secretion in CD4+ T cells and Contributes to Immune-mediated Organ Injury.Hepatology.?2017 ; 67(3):1027-1040
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